Derek’s death in Grey’s Anatomy was easily among the show’s most heartbreaking, changing it forever because of what it meant for Meredith, and it happening ten years ago means Grey’s Anatomy has existed as much time without Derek as with. Renowned for killing off its main characters, Grey’s Anatomy was always at its best when it led you to care about a character only to rip them from you, whether they were patients, first responders or doctors. Derek being a Grey’s Anatomy protagonist nonetheless made his death particularly heart-wrenching, for how it affected Meredith and the other Grey Sloan doctors.